The antral follicle: a microenvironment for oocyte differentiation

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The antral follicle: a microenvironment for oocyte differentiation.

Mammalian reproduction hinges upon the timely ovulation of a fully differentiated oocyte. This event is the culmination of a complex and dynamic developmental relationship between the oocyte and the antral follicle housing it; the antral follicle constitutes a specialized microenvironment or niche, uniquely suited to the needs of the oocyte as it approaches ovulation. During this time, the oocy...

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Follicle Structure Influences the Availability of Oxygen to the Oocyte in Antral Follicles

The ability of an oocyte to successfully mature is highly dependent on intrafollicular conditions, including the size and structure of the follicle. Here we present a mathematical model of oxygen transport in the antral follicle. We relate mean oxygen concentration in follicular fluid of bovine follicles to the concentration in the immediate vicinity of the cumulus-oocyte complex (COC). The mod...

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Antral Follicle Count

The number of antral follicles (a stage of folliculogenesis) determinates the quantity of oocytes potentially available for ovulation. It is one of the characteristics used to specify so called ovarian reserve which represents important factor to predict the result of IVF cycle, among other things. AFC can be set by usage of transvaginal ultrasonography (a sonography that applies an ultrasound ...

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Spontaneous antral follicle formation and metaphase II oocyte from a non-stimulated prepubertal ovarian tissue xenotransplant

BACKGROUND Current strategies in cancer treatment have markedly increased the rates of remission and survival for cancer patients, but are often associated with subsequent sterility. While there are various options available to an adult female depending on the patient's particular situation, the only realistic option for preserving fertility in prepubertal females is to cryopreserve ovarian tis...

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Different follicle-stimulating hormone exposure regimens during antral follicle growth alter gene expression in the cumulus-oocyte complex in mice.

Follicle-stimulating hormone (FSH) and oocyte-secreted factors influence granulosa cell differentiation and follicle development. Whereas FSH stimulates the expression of mural cell transcripts, oocyte-secreted factors regulate specific cumulus cell genes and suppress the appearance of mural cell transcripts. This study addresses the extent to which clinically relevant changes in FSH doses appl...

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ژورنال

عنوان ژورنال: The International Journal of Developmental Biology

سال: 2012

ISSN: 0214-6282

DOI: 10.1387/ijdb.120133cc